The LINC01176-miR-218-5p-IL-36G Network is Responsible for the Pathogenesis of Psoriasis by Promoting Inflammation.

Zongfeng ZhaoJie ChengWanqun SunJian ZhuSheng LuYanyan FengZhendong SongYali YangXiujuan Wu

Published in: Clinical, cosmetic and investigational dermatology (2024)

Our study shows that LINC01176 promotes the proliferation and invasion of keratinocytes and inhibits apoptosis by targeting miR-218-5p, which acts as a repressor of the psoriasis-associated IL-36G. The shRNA-LINC01176 emulsion showed potential treatment capability in alleviating symptoms of psoriasis.

Keyphrases

long non coding rna
long noncoding rna
cell proliferation
oxidative stress
atopic dermatitis
endoplasmic reticulum stress
cell death
cell cycle arrest
signaling pathway
combination therapy
human health
replacement therapy
wound healing