Real-world dose reduction of standard and modified FOLFIRINOX in metastatic pancreatic cancer: a systematic review, evidence-mapping, and meta-analysis.

Kwangrok JungSuhyun ChoiHyunjoo SongKyuhan KwakSoyeon AnhJae Hyup JungBomi KimJinwoo AhnJaihwan KimJin-Hyeok HwangJong-Chan Lee

Published in: Therapeutic advances in medical oncology (2023)

RDI-map.com enables multifactorial evidence-mapping for practical FOLFIRINOX dose reduction. The pattern of dose modification was not consistent across studies, and there was a significant gap between the 'planned' and 'actual' doses. Modified FOLFIRINOX showed similar efficacy to the standard regimen with reduced incidence of febrile neutropenia.

Keyphrases

locally advanced
high resolution
high density
squamous cell carcinoma
small cell lung cancer
rectal cancer
risk factors
radiation therapy
chemotherapy induced