Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NF-κB activation via disrupting multiple-site ubiquitination of NEMO.

Xiangqin KuangZhuojun ZhangDifeng LiWenhao BaoJinyuan PanPing ZhouHan ChenZhiqing GaoXiaoyi XieChunxiao YangGe ZhuZhongqiu ZhouRuiming TangZhengfu FengLihuan ZhouXiaoli FengLan WangJianan YangLili Jiang

Published in: Cellular & molecular biology letters (2023)

These results indicate that PI16 functions as a tumour suppressor in BLCA by inhibiting tumour growth and metastasis. Additionally, PI16 may serve as a potential biomarker for metastatic BLCA.

Keyphrases

signaling pathway
squamous cell carcinoma
small cell lung cancer
pi k akt
lps induced
nuclear factor
toll like receptor