Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.

Subhodip Adhicary Kayleigh Fanelli Sera Nakisli Brittney Ward Isaac Pearce Corinne M Nielsen

Published in: Stroke (2023)

Our data suggest that endothelial Rbpj promotes rearrangement of brain ECs during cerebrovascular remodeling, through Apelin/Apj-mediated small GTPase activity, and prevents bAVM. By inhibiting Apelin/Apj signaling in vivo, we demonstrated pharmacological prevention of Rbpj-mediated bAVM.

Keyphrases

resting state
white matter
functional connectivity
single cell
signaling pathway
cell therapy
cerebral ischemia
electronic health record
stem cells
mouse model
bone marrow
deep learning
blood brain barrier
replacement therapy
brain injury