Rational Design and Identification of Novel Thiosemicarbazide Derivatives as Laccase Inhibitors.

Thirty-eight compounds were synthesized and showed good inhibitory activity against laccase, the introduction of morpholine and piperazine in amino part was beneficial to improve antifungal activity and laccase activity. Further validation of laccase as a potential target for rice blast control, while m14 can be used as a candidate compound for the control of rice blast. This article is protected by copyright. All rights reserved.