Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion.
Laura PoddigheGianfranca CartaMaria Pina SerraTiziana MelisMarianna BoiSara LisaiElisabetta MurruLaura MureddaMaria ColluSebastiano BanniMarina QuartuPublished in: Lipids in health and disease (2018)
Collectively, the pre-treatment with BCP, likely acting as agonist for CB2 and PPAR-alpha receptors, modulates in a beneficial way the ECS activation and the lipoperoxidation, taken as indicative of oxidative stress. Furthermore, our results support the evidence that BCP may be used as a dietary supplement to control the physiological response to the hypoperfusion/reperfusion-induced oxidative stress.
Keyphrases
- cerebral ischemia
- oxidative stress
- acute myocardial infarction
- subarachnoid hemorrhage
- liver failure
- acute ischemic stroke
- blood brain barrier
- brain injury
- dna damage
- hydrogen peroxide
- drug induced
- ischemia reperfusion injury
- aortic dissection
- intensive care unit
- combination therapy
- acute coronary syndrome
- percutaneous coronary intervention
- skeletal muscle
- mechanical ventilation
- acute respiratory distress syndrome
- smoking cessation