Pre-treatment or post-treatment with hydroxychloroquine demonstrate neuroprotective effects in cerebral ischemia/reperfusion.

Shabnam BabataheriHassan MalekinejadArash MosarrezaiiHamid Soraya

Published in: Fundamental & clinical pharmacology (2022)

Our results show the neuroprotective effects of HCQ on cerebral I/R through the reduction in infarct size, histopathological changes, as well as improvement in memory and learning functions. Moreover, AMPK and autophagy may play a role in this protective effect.

Keyphrases

subarachnoid hemorrhage
signaling pathway
endoplasmic reticulum stress
coronary artery disease
acute coronary syndrome
percutaneous coronary intervention
brain injury
cerebral ischemia
replacement therapy
smoking cessation