Cyclic bisphosphonate therapy reduces pain and improves physical functioning in children with osteogenesis imperfecta.

Melissa D GargantaSarah S JaserMargot A LazowJonathan G SchoeneckerErin CobryStephen R HaysJill H Simmons

Published in: BMC musculoskeletal disorders (2018)

In children with OI, cyclic intravenous bisphosphonate therapy transiently reduces pain and improves functional abilities. Pain relief occurs immediately following infusion with functional improvements observed 4 weeks later. Both pain and physical functioning return to pretreatment levels by the subsequent infusion.

Keyphrases

chronic pain
pain management
neuropathic pain
young adults
mental health
physical activity
low dose
high dose
spinal cord injury
mesenchymal stem cells