Associations of Body Mass Index With Pain and the Mediating Role of Inflammatory Biomarkers in People With Hand Osteoarthritis.

Marthe Gløersen Pernille Steen Pettersen Tuhina Neogi S Reza JafarzadehMaria VistnesChristian S ThudiumAnne-Christine Bay-JensenJoe SextonTore K Kvien Hilde Berner Hammer Ida K Haugen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

In people with hand OA, higher BMI is associated with greater pain severity in the hands, feet, and knees/hips. Systemic effects of obesity, measured by leptin, may play a larger mediating role for pain in the hands than in the lower extremities. Low-grade inflammation, measured by hsCRP, may contribute to generalized pain in overweight/obese individuals.

Keyphrases

chronic pain
body mass index
low grade
pain management
neuropathic pain
weight loss
metabolic syndrome
type diabetes
oxidative stress
physical activity
adipose tissue
insulin resistance
bariatric surgery
spinal cord injury
high fat diet induced
obese patients
anterior cruciate ligament