Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer.
Andrew A DavisQiang ZhangLorenzo GerratanaAmi N ShahYoubin ZhanWenan QiangBrian S FinkelmanLisa FlaumAmir BehdadWilliam J GradisharLeonidas C PlataniasMassimo CristofanilliPublished in: Breast cancer research : BCR (2019)
We report on a novel ctDNA platform that detected genomic alterations in the vast majority of tested patients, further indicating potential clinical utility for capturing disease heterogeneity and for disease monitoring. Detection of CTCs and CTC clusters was associated with particular genomic profiles.
Keyphrases
- circulating tumor cells
- circulating tumor
- metastatic breast cancer
- end stage renal disease
- single cell
- high throughput
- newly diagnosed
- ejection fraction
- chronic kidney disease
- copy number
- prognostic factors
- cell free
- patient reported outcomes
- gene expression
- dna methylation
- risk assessment
- patient reported
- sensitive detection