A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes.

Yaser Hadi Gholami Lee JosephsonEman A AkamPeter CaravanMoses Q WilksXiang-Zuo Pan Richard MaschmeyerAleksandra KolnickGeorges Ei Fakhri Marc D Normandin Zdenka KuncicHushan Yuan

Published in: International journal of nanomedicine (2020)

The chelate-free HIR technique for binding metals to FH NPs has been extended to a range of metals with radioisotopes used in therapeutic and diagnostic applications. Cations with f-orbital electrons, more empty d-orbitals, larger radii, and higher positive charges achieved higher values of RCY and RCP in the HIR reaction. The ability to use a simple heating step to bind a wide range of metals to the FH NP, a widely available approved drug, may allow this NP to become a platform for obtaining radiolabeled nanoparticles in many settings.

Keyphrases

human health
health risk
health risk assessment
high throughput
risk assessment
heavy metals
drinking water
density functional theory
ionic liquid
climate change
binding protein
dna binding
drug induced
transcription factor
adverse drug