A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling.

Xinxin ZhangXiangyu XuLi LuXiaoning WanYating QinWeibin RuanChao LvLin HeXiaomei Guo

Published in: Journal of translational medicine (2021)

Taken together, the present study showed that MRSP treatment results in a strong proapoptotic effect by activating the mitochondrial apoptotic cascade through suppression of the PI3K/Akt pathway.

Keyphrases

smooth muscle
signaling pathway
cell death
oxidative stress
cell proliferation
anti inflammatory