A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth.
Fan YangJezabel Rodriguez-BlancoJun LongMarzena Swiderska-SynDaniel T WynnBin LiChen ShenAnmada NayakYuguang J BanXiaodian SunRobert K SuterHeather J McCreaAnthony J CapobiancoNagi G AyadDavid J RobbinsPublished in: Molecular cancer research : MCR (2022)
This work describes a novel, druggable UHRF1/DNMT1/GLI complex that regulates SHH-dependent tumor growth, and highlights an FDA-approved drug capable of disrupting this complex to attenuate tumor growth.