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Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering.

Conor Timothy BuckleyJudith A HoylandKengo FujiiAbhay PanditJames C IatridisSybille Grad
Published in: JOR spine (2018)
Low back pain represents the highest burden of musculoskeletal diseases worldwide and intervertebral disc degeneration is frequently associated with this painful condition. Even though it remains challenging to clearly recognize generators of discogenic pain, tissue regeneration has been accepted as an effective treatment option with significant potential. Tissue engineering and regenerative medicine offer a plethora of exploratory pathways for functional repair or prevention of tissue breakdown. However, the intervertebral disc has extraordinary biological and mechanical demands that must be met to assure sustained success. This concise perspective review highlights the role of the disc microenvironment, mechanical and clinical design considerations, function vs mimicry in biomaterial-based and cell engineering strategies, and potential constraints for clinical translation of regenerative therapies for the intervertebral disc.
Keyphrases
  • tissue engineering
  • stem cells
  • cell therapy
  • single cell
  • human health
  • risk factors
  • big data
  • replacement therapy
  • smoking cessation