Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population.
Shahbaz KhanAmit Kumar VermaVasiuddin KhanDeepti BhattSahar RafatMohammed A AlsahliArshad Husain RahmaniBabita MeenaIrshad Husain NaqviKapil DevPublished in: Diabetes therapy : research, treatment and education of diabetes and related disorders (2020)
The present study concludes that there is no direct association of rs9939609 of the FTO gene with the occurrence of diabetes in the Indian population, but its role in T2D development cannot be overlooked altogether. Furthermore, we conclude that the rs9939609 of FTO carries a potential risk of obesity and because of this FTO rs9939609 T > A is widely considered an obesity-associated allele/single-nucleotide polymorphism (SNP).