Characterization of Factors Affecting the Detection Limit of EGFR p.T790M in Circulating Tumor DNA.

Ibrahim FahoumRelly ForerDina VolodarskyInna VulihTova BickShada SarjiZeev BambergerOfer Ben-IzhakEdmond SaboRuth HershbergIbrahim Fahoum

Published in: Technology in cancer research & treatment (2018)

Both the sequencing platform and the specific nucleotide change affect the limit of detection and should therefore be determined in the validation process of new assays.

Keyphrases

circulating tumor
cell free
circulating tumor cells
loop mediated isothermal amplification
high throughput
small cell lung cancer
label free
real time pcr
epidermal growth factor receptor
tyrosine kinase
single cell
single molecule