Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.

Qin TangLiwen RenJinyi LiuWan LiXiangjin ZhengJinhua WangGuanhua Du

Published in: Cell proliferation (2019)

We revealed a novel pathway that elucidated WA activation of apoptosis and G2/M arrest in GBM cells through the ATF4-ATF3-CHOP axis. This discovery is important for optimization of WA-based regimens for prevention and/or treatment of GBM.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
cell cycle arrest
cell death
transcription factor
pi k akt
oxidative stress
diffuse large b cell lymphoma
cell cycle
small molecule
high throughput
single cell
combination therapy