NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance.
Yvonne M MoweryJason John LukePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
NETosis via lytic neutrophil death or neutrophil activation is associated with standard cancer therapies, notably including radiotherapy, is immunosuppressive, and may enhance metastasis and treatment resistance. This emerging area of research should be prioritized in drug development and standard of care treatment paradigms including radiation, chemo- and immunotherapy.