Alobar holoprosencephaly in mining-related areas of the Eastern region of the Democratic Republic of the Congo: A case series.

Paterne Safari MudekerezaJules Balagizi MudekerezaGauthier Murhula BahizireHervé Monka LekuyaEdouard Amani MudekerezaGermain Mudumbi ZabadayiPaul Munguakonkwa BudemaPatrick Birindwa BalungweDominique ChimanukaLéon-Emmanuel Mukengeshai Mubenga

Published in: Birth defects research (2021)

The etiologic factors of HPE remain unknown but seem to be multifactorial from both genetic and environmental factors. We hypothesize under reserve for these two cases that mining and radiation expositions were likely potential environmental associated factors to the occurrence of these malformations.

Keyphrases

human health
risk assessment
south africa
genome wide
copy number
gene expression
climate change
radiation therapy
radiation induced
dna methylation