The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster.
Cecilia CerretaniMikkel Baldtzer LiisbergVanessa RückJiro KondoTom VoschPublished in: Nanoscale advances (2022)
The effect of replacing guanosines with inosines in the two stabilizing strands (5'-CACCTAGCGA-3') of the NIR emissive DNA-Ag 16 NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes.
Keyphrases
- single molecule
- molecular docking
- circulating tumor
- fluorescent probe
- photodynamic therapy
- cell free
- quantum dots
- drug release
- gold nanoparticles
- fluorescence imaging
- high resolution
- energy transfer
- atomic force microscopy
- healthcare
- magnetic resonance
- magnetic resonance imaging
- light emitting
- silver nanoparticles
- contrast enhanced
- visible light