Parvovirus B19 infection masquerading as relapsed acute lymphoblastic leukaemia following haematopoietic stem cell transplantation.
Trisha LarkinPeng LiBiljana HornPublished in: BMJ case reports (2020)
A 7-year-old boy presented with a constellation of bone pain, a skeletal lesion, and pancytopenia after undergoing allogeneic haematopoietic stem cell transplantation for recurrent acute B-cell lymphoblastic leukaemia. Investigations to rule out leukaemia recurrence were unremarkable. Due to presence of maturation arrest in erythropoiesis with giant pronormoblasts and aberrant intranuclear inclusions on a bone marrow aspirate, parvovirus B19 (PVB-19) staining was completed and confirmed the diagnosis of disseminated PVB-19. Though PVB-19 infection after solid organ transplantation was reported in the literature as early as 1986, acquired PVB-19 viremia presenting with a solitary bone lesion is a novel presentation in paediatrics.
Keyphrases
- stem cell transplantation
- high dose
- liver failure
- bone marrow
- respiratory failure
- bone mineral density
- chronic pain
- drug induced
- aortic dissection
- systematic review
- acute lymphoblastic leukemia
- acute myeloid leukemia
- soft tissue
- mesenchymal stem cells
- bone loss
- diffuse large b cell lymphoma
- neuropathic pain
- pain management
- low dose
- bone regeneration
- rare case
- hepatitis b virus
- cell therapy
- free survival
- body composition
- spinal cord
- spinal cord injury
- cell proliferation