Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study.
Aileen Y ChangSarah R TritschCarlos Andres Herrera GomezLiliana EncinalesAndres Cadena BonfantiWendy RosalesEvelyn Mendoza-TorresSamuel J SimmensRichard L AmdurChristopher N MoresPaige FierbaughCarlos Alberto Perez HernandezGeraldine AvendañoPaula Bruges SilveraYerlenis Galvis CrespoAlberto David Cabana JimenezJennifer Carolina Martinez ZapataDennys JimenezEstefanie Osorio-LlanesJairo Castellar-LopezKarol SuchowieckiKaren MartinsMelissa GregoryIvan ZuluagaAbigale ProctorAlfonso Sucerquia HernándezLeandro Sierra-CarreroMaria Villanueva ColpasJuan Carlos Perez HernandezAndres Alberto Figueroa QuastJoaquin Andres Calderon De BarrosJosé Forero MejíaJohan Penagos RuizDavid BoyleGary S FiresteinGary L SimonPublished in: PloS one (2024)
Chikungunya arthritis is characterized by increased inflammatory cytokines and deficient IL-2 and Treg responses. Greater levels of IL-2 were associated with improved Treg numbers and immunosuppressive markers. Future research may consider targeting these pathways for therapy.