SAGA-CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity.

Carme Nuño-CabanesVarinia García-MolineroManuel Martín-ExpósitoMaría-Eugenia GasPaula Oliete-CalvoEncar García-OliverMaría de la Iglesia-VayáSusana Rodríguez-Navarro

Published in: Epigenetics & chromatin (2020)

Collectively, our studies show that the DUBm tetrameric structure can form without a complete intact SAGA-CORE complex and that it includes full-length Sgf73. However, subunits of this SAGA-CORE influence DUBm association with chromatin, its localization and its activity.

Keyphrases

gene expression
dna damage
transcription factor
genome wide
dna methylation
case control