Characteristics and outcomes of gemcitabine-associated pulmonary hypertension.
Pierre MouillotNicolas FavroltCharles KhouriAurélie GrandvuilleminMarie-Camille ChaumaisDéborah SchenesseAndrei SeferianXavier JaisLaurent SavaleGuillaume BeltramoOlivier SitbonJean-Luc CracowskiMarc HumbertMarjolaine GeorgesPhilippe BonniaudI David MontaniPublished in: ERJ open research (2024)
Both clinical cases and pharmacovigilance data substantiate a significant association between gemcitabine use and the onset or worsening of precapillary PH. The observed improvement following the discontinuation of treatment underscores the importance of PH screening in gemcitabine-exposed patients experiencing unexplained dyspnoea.