An L-type calcium channel blocker nimodipine exerts anti-fibrotic effects by attenuating TGF-β1 induced calcium response in an in vitro model of thyroid eye disease.
Qian ChenYuan PanYunwei HuGuanyu ChenXiaoqing ChenYanyan XieMinzhen WangZhuang LiJun HuangYuxun ShiHaixiang HuangTe ZhangMei WangPeng ZengSha WangRongxin ChenYongxin ZhengLiuxueying ZhongHuasheng YangDan LiangPublished in: Eye and vision (London, England) (2024)
response, followed by activation of CaMKII/STAT1 signaling pathway, which promotes the pro-fibrotic functions of OFs and participates in fibrogenesis during TED. Nimodipine exerts potent anti-fibrotic benefits in vitro by suppressing the CaMKII/STAT1 signaling pathway. Our work deepens our understanding of the fibrogenesis process during TED and provides potential therapeutic targets and alternative candidate for TED.