MSCs biomimetic ultrasonic phase change nanoparticles promotes cardiac functional recovery after acute myocardial infarction.
Zhuo WangJianfeng ChenJiaxu WangMingyuan XuHaichao YangHaobo YangChen ZhaoPing SunHuan JiJinhong LiuJiaxin ShanJiawei TianShouqiang LiDandan YuChao WangXinhong YuShuo DingWenjun XuYing ZhangXiaoping LengThomas R-PorterPublished in: Biomaterials (2024)
Acute Myocardial Infarction (AMI) has seen rising cases, particularly in younger people, leading to public health concerns. Standard treatments, like coronary artery recanalization, often don't fully repair the heart's microvasculature, risking heart failure. Advances show that Mesenchymal Stromal Cells (MSCs) transplantation improves cardiac function after AMI, but the harsh microenvironment post-AMI impacts cell survival and therapeutic results. MSCs aid heart repair via their membrane proteins and paracrine extracellular vesicles that carry microRNA-125b, which regulates multiple targets, preventing cardiomyocyte death, limiting fibroblast growth, and combating myocardial remodeling after AMI. This study introduces ultrasound-responsive phase-change bionic nanoparticles, leveraging MSCs' natural properties. These particles contain MSC membrane and microRNA-125b, with added macrophage membrane for stability. Using Ultrasound Targeted Microbubble Destruction (UTMD), this method targets the delivery of MSC membrane proteins and microRNA-125b to AMI's inflamed areas. This aims to enhance cardiac function recovery and provide precise, targeted AMI therapy.
Keyphrases
- acute myocardial infarction
- left ventricular
- heart failure
- mesenchymal stem cells
- percutaneous coronary intervention
- public health
- coronary artery
- umbilical cord
- cancer therapy
- cardiac resynchronization therapy
- magnetic resonance imaging
- atrial fibrillation
- bone marrow
- coronary artery disease
- stem cells
- adipose tissue
- angiotensin ii
- pulmonary artery
- middle cerebral artery
- endothelial cells
- smoking cessation
- pulmonary arterial hypertension
- acute heart failure
- pulmonary hypertension
- tissue engineering