Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins.
Lijie WangAfsaneh MohammadnejadWeilong LiJesper Beltoft LundShuxia LiSigne Bedsted ClemmensenMaria N TimofeevaMette SørensenJonas Mengel-FromKaare ChristensenJacob V B HjelmborgQihua TanPublished in: Clinical epigenetics (2021)
We have identified 6 CpG sites linked to the MGMT gene with strong and persistent genetic control based on their DNA methylation levels. The genetic basis of MGMT gene methylation could help to explain individual differences in glioblastoma treatment response and most importantly, provide references for mapping the methylation Quantitative Trait Loci (meQTL) underlying the genetic regulation.