Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins.

Lijie Wang Afsaneh Mohammadnejad Weilong Li Jesper Beltoft Lund Shuxia Li Signe Bedsted Clemmensen Maria N Timofeeva Mette Sørensen Jonas Mengel-From Kaare Christensen Jacob V B Hjelmborg Qihua Tan

Published in: Clinical epigenetics (2021)

We have identified 6 CpG sites linked to the MGMT gene with strong and persistent genetic control based on their DNA methylation levels. The genetic basis of MGMT gene methylation could help to explain individual differences in glioblastoma treatment response and most importantly, provide references for mapping the methylation Quantitative Trait Loci (meQTL) underlying the genetic regulation.

Keyphrases

genome wide
dna methylation

copy number
gene expression

high resolution
circulating tumor

circulating tumor cells