Dendritic cells, macrophages, NK and CD8+ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B.
Natália LucindaMaria Marta FigueiredoNatália Lima PessoaBeatriz Senra Álvares da Silva SantosGraciela Kunrath LimaArthur Molinari FreitasAlexandre Magalhães Vieira MachadoErna Geessien KroonLis Ribeiro do Valle AntonelliMarco Antônio CamposPublished in: Virology journal (2017)
Taken together, our data provide strong evidence that the responses mediated by DCs, Mo/Mϕ, NK and CD8+ T lymphocytes through IL-1β, iNOS and granzyme B production, respectively, together with the production of type I IFN early in the infection, are crucial to host defense against HSV-1.