Severe Impairment of T-cell Immunity and Pulmonary GvHD Are Major Risk Factors for Nontuberculous Mycobacterial Infection After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation.
Marina AscunceAlejandra CoccoloYasmina MozoFernando Baquero-ArtigaoPaula Rodriguez-MolinoCarlos Toro-RuedaPaloma García-ClementeElena Sánchez-ZapardielEduardo López-GranadosDolores Corral-SánchezDavid BuenoLuisa SisinniAntonio Pérez-MartínezCristina CalvoTeresa Del RosalPublished in: The Pediatric infectious disease journal (2024)
Hematopoietic stem cell transplant recipients are prone to infectious complications. Infections caused by nontuberculous mycobacteria have increased in adults but literature in children is scarce. We report 6 episodes of disseminated or pulmonary nontuberculous mycobacteria infection among 5 pediatric hematopoietic stem cell transplant recipients. All but one were caused by Mycobacterium avium complex. Four patients died, 2 related to nontuberculous mycobacteria infection.
Keyphrases
- hematopoietic stem cell
- allogeneic hematopoietic stem cell transplantation
- end stage renal disease
- pulmonary hypertension
- mycobacterium tuberculosis
- acute myeloid leukemia
- acute lymphoblastic leukemia
- systematic review
- ejection fraction
- chronic kidney disease
- young adults
- peritoneal dialysis
- prognostic factors
- drug induced