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The genetic legacy of African Americans from Catoctin Furnace.

Éadaoin HarneySteven J MichelettiKarin S BruwelheideWilliam A FreymanKatarzyna BrycAli AkbariEthan JewettElizabeth ComerHenry Louis GatesLinda HeywoodJohn ThorntonRoslyn CurrySamantha Ancona EsselmannKathryn G BarcaJakob SedigKendra A SirakIñigo OlaldeNicole AdamskiRebecca BernardosNasreen BroomandkhoshbachtMatthew FerryLijun QiuKristin StewardsonJ Noah WorkmanFatma ZalzalaShop MallickAdam MiccoMatthew MahZhao Zhangnull nullNadin RohlandJoanna L MountainDouglas W OwsleyDavid Reichnull null
Published in: Science (New York, N.Y.) (2023)
Few African Americans have been able to trace family lineages back to ancestors who died before the 1870 United States Census, the first in which all Black people were listed by name. We analyzed 27 individuals from Maryland's Catoctin Furnace African American Cemetery (1774-1850), identifying 41,799 genetic relatives among consenting research participants in 23andMe, Inc.'s genetic database. One of the highest concentrations of close relatives is in Maryland, suggesting that descendants of the Catoctin individuals remain in the area. We find that many of the Catoctin individuals derived African ancestry from the Wolof or Kongo groups and European ancestry from Great Britain and Ireland. This study demonstrates the power of joint analysis of historical DNA and large datasets generated through direct-to-consumer ancestry testing.
Keyphrases
  • african american
  • genome wide
  • copy number
  • genome wide association study
  • healthcare
  • heavy metals
  • circulating tumor
  • cell free
  • gene expression
  • single cell
  • electronic health record