Network pharmacology and experimental verification: Unraveling Zhiwei Fuwei Pills's role and mechanism in angiogenesis of precancerous lesions of gastric cancer.

Pengcheng DouRuiping SongZhuangzhuang FengBing JiangXinyi ChenYuanbin LuoJiaojiao ZuoYi GaoJin Shu

Published in: Human & experimental toxicology (2024)

ZWFW can intervene in the neovascularization and pathological evolution of PLGC, and this mechanism of action may be achieved by inhibiting abnormal activation of the PI3K/Akt/mTOR/HIF-1α/VEGF signaling pathway.

Keyphrases

vascular endothelial growth factor
signaling pathway
endothelial cells
pi k akt
epithelial mesenchymal transition
induced apoptosis
diabetic retinopathy
cell proliferation
wound healing
network analysis