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Comprehensive Analysis of Penicillium Sclerotiorum : Biology, Secondary Metabolites, and Bioactive Compound Potential─A Review.

Israt JahanYihan WangPing LiSarfaraz HussainJiayi SongJian Yan
Published in: Journal of agricultural and food chemistry (2024)
The filamentous fungus Penicillium sclerotiorum is significant in ecological and industrial domains due to its vast supply of secondary metabolites that have a diverse array of biological functions. We have gathered the metabolic potential and biological activities associated with P. sclerotiorum metabolites of various structures, based on extensive research of the latest literature. The review incorporated literature spanning from 2000 to 2023, drawing from reputable databases including Google Scholar, ScienceDirect, Scopus, and PubMed, among others. Ranging from azaphilones, meroterpenoids, polyketides, and peptides group exhibits fascinating potential pharmacological activities such as antimicrobial, anti-inflammatory, and antitumor effects, holding promise in pharmaceutical and industrial sectors. Additionally, P. sclerotiorum showcases biotechnological potential through the production of enzymes like β-xylosidases, β-d-glucosidase, and xylanases, pivotal in various industrial processes. This review underscores the need for further exploration into its genetic foundations and cultivation conditions to optimize the yield of valuable compounds and enzymes, highlighting the unexplored potential of P. sclerotiorum in diverse applications across industries.
Keyphrases
  • systematic review
  • wastewater treatment
  • ms ms
  • heavy metals
  • anti inflammatory
  • machine learning
  • mass spectrometry
  • dna methylation
  • genome wide
  • high throughput
  • artificial intelligence