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Gain-of-function mutations in Trim71 linked to congenital hydrocephalus.

Yingying ChenXianfa YangNaihe Jing
Published in: PLoS biology (2023)
The genetic basis of congenital hydrocephalus is only partially understood. A new study in PLOS Biology reports a potential gain-of-function pathological mechanism of congenital hydrocephalus in mouse embryonic stem cells that involves Wnt-β-catenin signaling pathway regulation.
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