CASPR2 autoimmunity in children expanding to mild encephalopathy with hypertension.
Steffen SyrbeGeorg M StettnerJulien BallyIngo BorggraefeCorinna I BienRuxandra Iancu FerfogliaPeter HuppkeJan KernTilman PolsterElisabeth Probst-MüllerSilvia SchmidRobert SteinfeldSusi StrozziAnnette WeichselbaumMarcus WeitzAndreas ZieglerKlaus-Peter WandingerFrank LeypoldtChristian G BienPublished in: Neurology (2020)
High-titer CASPR2 antibodies are associated with Morvan syndrome in children as young as 2 years. However, CASPR2 autoimmunity mimics systemic disease and hypertensive encephalopathy in children younger than 7 years. The outcome following immunotherapy was mostly favorable; long-term behavioral impairment may occur in younger children.
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