High-Resolution Haplotyping of the PAH Gene Enables Early Gestation Noninvasive Prenatal Diagnosis of Phenylketonuria and Evolution Analysis of Recurrent Pathogenic Variations.
Jingqi ZhuZhenhua ZhaoShaojun LiYifan ZhouLingrong KongXiangdong KongHuanyun LiJun FengWeiqin TangDi WuXiangdong KongPublished in: Prenatal diagnosis (2024)
This study validates the feasibility of an RHDO-based assay for NIPD of PKU in early pregnancy and introduces its application in the demonstration of founder effects in recurrent pathogenic variations, offering new insights into the evolutionary analysis of PAH variations.