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Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions.

Zhiquan LiuSiyu ChenHuanhuan ShanYingqi JiaMao ChenYuning SongLiangxue LaiZhanjun Li
Published in: BMC biology (2020)
These novel base editors with improved precision and CC context-specificity will expand the toolset for precise gene modification in organisms.
Keyphrases
  • endothelial cells
  • crispr cas
  • structural basis
  • induced pluripotent stem cells
  • copy number
  • genome wide
  • gram negative
  • dna methylation
  • transcription factor