The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling.

Chunfang TaoJuan LuoJun TangDanfeng ZhouShujun FengZhu QiuThomas C PuttiTingxiu XiangQiao TaoLili LiGuo-Sheng Ren

Published in: Clinical epigenetics (2020)

ZNF471 functions as a tumor suppressor that was epigenetically inactivated in breast cancer. Its inhibition of AKT and Wnt/β-catenin signaling pathways is one of the mechanisms underlying its anti-cancer effects.

Keyphrases

signaling pathway
cell proliferation
epithelial mesenchymal transition
pi k akt
stem cells
induced apoptosis
long noncoding rna
young adults
binding protein
small molecule