Increased CD8 Tumor Infiltrating Lymphocytes in Colorectal Cancer Microenvironment Supports an Adaptive Immune Resistance Mechanism of PD-L1 Expression.
Aru W SudoyoAntonius N KurniawanGita D KusumoTeguh P PutraFritzie A RexanaMuhammad YunusAkterono D BudiyatiDicky KurniawanAndi UtamaAhmad Rusdan Handoyo UtomoPublished in: Asian Pacific journal of cancer prevention : APJCP (2019)
Our study demonstrated that PD-L1 expressions in CRC were predominantly found as a consequence of infiltrating CD8 T lymphocytes that in part arise in the setting of microsatellite instability. Taken together, our findings further support the role of adaptive immune resistance to drive PD-L1 induction in tumor microenvironment and may provide important rationale for strategy implementation of immunotherapy for CRC cases.<br />.