Long-term yield of pancreatic cancer surveillance in high-risk individuals.
Kasper Alexander OverbeekIris J M LevinkBrechtje D M KoopmannFemme HarinckIngrid C A W KoningsMargreet G E M AusemsAnja WagnerPaul FockensCasper H J van EijckBas Groot KoerkampOlivier R C BuschMarc G H BesselinkBarbara A J BastiaansenLydi M J W van DrielNicole Stephanie ErlerFrank P VleggaarJan-Werner PoleyDjuna L CahenJeanin E van HooftMarco J Brunonull nullPublished in: Gut (2021)
The diagnostic yield of PDAC was substantial in established high-risk mutation carriers, but non-existent in the mutation-negative proven FPC kindreds. Nevertheless, timely identification of resectable lesions proved challenging despite the concurrent use of two imaging modalities, with EUS outperforming MRI/MRCP. Overall, surveillance by imaging yields suboptimal results with a clear need for more sensitive diagnostic markers, including biomarkers.