Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson's disease.

Nicola J RayRachael A LawsonSarah L MartinHilmar P SigurdssonJoanna WilsonBrook GalnaSue LordLisa AlcockGordon W DuncanTien K KhooJohn Tiernan O'BrienDavid J BurnJohn-Paul TaylorRiver C ReaMaurizio BergaminoLynn RochesterAlison J Yarnall

Published in: Brain : a journal of neurology (2022)

Free water and free-water-corrected DTI can index cholinergic degeneration that could enable stratification of patients in clinical trials of cholinergic interventions for cognitive decline. In addition, degeneration of the PPN impairs behavioural flexibility in Parkinson's, which may explain this region's role in increased risk of falls.

Keyphrases

cognitive decline
clinical trial
mild cognitive impairment
end stage renal disease
ejection fraction
newly diagnosed
high resolution
chronic kidney disease
prognostic factors
physical activity
multiple sclerosis
white matter
study protocol
photodynamic therapy
phase iii
placebo controlled