Urine complement proteins are associated with kidney disease progression of type 2 diabetes in Korean and American cohorts.
Donghwan YunSohyun BaeYuqian GaoLauren LopezDo Hyun HanCarrie D NicoraTae Youn KimKyung Chul MoonDong-Ki KimThomas L FillmoreYon Su KimAvi Z RosenbergWeijie WangPinaki SarderWei-Jun QianMaryam AfkarianSeung Seok HanPublished in: medRxiv : the preprint server for health sciences (2024)
Urinary proteomic profiling confirms the association between the complement pathway and rapid DKD progression in two independent cohorts. These results suggest a need to further investigate complement pathway inhibition as a novel treatment for DKD.