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Effects of cyclophosphamide administration on ovarian dysfunction in pediatric patients with connective tissue diseases: A systematic scoping review.

Ken-Ei SadaTakako MiyamaeKayoko KanekoSakiko IsojimaKunihiro IchinoseMasakazu MatsushitaKenji OkuYasunori IwataKeishi FujioAtsuko MurashimaYoshiya TanakaAyako Nakajima
Published in: Modern rheumatology (2024)
This review suggested that CY use in childhood may not conclusively have clinically significant effects on ovarian function. Further investigation needed on CY's effect on hormonal levels, fertility, and pregnancy outcomes.
Keyphrases
  • pregnancy outcomes
  • pregnant women
  • childhood cancer
  • low dose
  • high dose
  • oxidative stress
  • type diabetes
  • early life
  • metabolic syndrome
  • insulin resistance