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Availability of individual proteins for quantitative analysis in postmortem brains preserved in two different brain banks.

Atsuko NagaokaMizuki HinoRyuta IzumiRisa ShishidoMiki IshibashiMasataka HatanoMakoto SainouchiAkiyoshi KakitaHiroaki TomitaYasuto Kunii
Published in: Neuropsychopharmacology reports (2024)
When studies are conducted using brain samples preserved in different brain banks, differences in demographic factors should be carefully considered and taken into account by statistical methods to minimize their impact as much as possible. Since there was no significant difference in the protein expression levels of GAPDH and GFAP in either region between the two institutions that preserved the postmortem brains, we concluded that it is possible to perform protein quantitative analysis assuming that there is no effect of difference between two institutions.
Keyphrases
  • resting state
  • white matter
  • functional connectivity
  • multiple sclerosis
  • small molecule
  • protein protein
  • binding protein