B cells expressing mutated IGHV1-69-encoded antigen receptors related to virus neutralization show lymphoma-like transcriptomes in patients with chronic HCV infection.
Christoph SchultheißEdith WillscherLisa PascholdChristin AckermannMoritz EscherRebekka ScholzMaximilian KnappJana LützkendorfLutz Peter MüllerJulian Schulze Zur-WieschMascha BinderPublished in: Hepatology communications (2024)
We provide evidence that lymphoma-like cells derive from the anti-HCV immune response. In many patients, these cells persist for years after SVR and can be interpreted as a mechanistic basis for HCV-related B cell dyscrasias and increased lymphoma risk even beyond viral elimination.
Keyphrases
- hepatitis c virus
- diffuse large b cell lymphoma
- immune response
- end stage renal disease
- ejection fraction
- induced apoptosis
- newly diagnosed
- human immunodeficiency virus
- sars cov
- peritoneal dialysis
- cell cycle arrest
- toll like receptor
- endoplasmic reticulum stress
- signaling pathway
- dendritic cells
- oxidative stress
- inflammatory response