Evaluation of the transcriptional immune biomarkers in peripheral blood from Warao indigenous associate with the infection by Mycobacterium tuberculosis.
Zaida AraujoAndrea PalaciosLeonor Enciso-MorenoJuan Ernesto Lopez-RamosAlbina WideJacobus Henri de WaardBruno Rivas-SantiagoCarmen Judith SerranoYadira Bastian-HernandezJulio Enrique Castañeda-DelgadoJose Antonio Enciso-MorenoPublished in: Revista da Sociedade Brasileira de Medicina Tropical (2019)
Preliminary findings showed that MMP9 immune biomarkers separated LTBI indigenous individuals from NIC indigenous individuals, while CCR5, CCL11, CD14, and IFN-γ did not differentiate TB states from NIC. MMP9 may be useful as a potential biomarker for LTBI and new infected case detection among Warao indigenous individuals at high risk of developing the disease. It may also be used to halt the epidemic, which will require further validation in larger studies.