Hybridized quantum dot, silica, and gold nanoparticles for targeted chemo-radiotherapy in colorectal cancer theranostics.
Amir AbrishamiAhmad Reza BahramiSirous NekooeiAmir Sh SaljooghiMaryam M MatinPublished in: Communications biology (2024)
Multimodal nanoparticles, utilizing quantum dots (QDs), mesoporous silica nanoparticles (MSNs), and gold nanoparticles (Au NPs), offer substantial potential as a smart and targeted drug delivery system for simultaneous cancer therapy and imaging. This method entails coating magnetic GZCIS/ZnS QDs with mesoporous silica, loading epirubicin into the pores, capping with Au NPs, PEGylation, and conjugating with epithelial cell adhesion molecule (EpCAM) aptamers to actively target colorectal cancer (CRC) cells. This study showcases the hybrid QD@MSN-EPI-Au-PEG-Apt nanocarriers (size ~65 nm) with comprehensive characterizations post-synthesis. In vitro studies demonstrate the selective cytotoxicity of these targeted nanocarriers towards HT-29 cells compared to CHO cells, leading to a significant reduction in HT-29 cell survival when combined with irradiation. Targeted delivery of nanocarriers in vivo is validated by enhanced anti-tumor effects with reduced side effects following chemo-radiotherapy, along with imaging in a CRC mouse model. This approach holds promise for improved CRC theranostics.
Keyphrases
- cancer therapy
- drug delivery
- gold nanoparticles
- induced apoptosis
- quantum dots
- cell adhesion
- cell cycle arrest
- sensitive detection
- reduced graphene oxide
- photodynamic therapy
- locally advanced
- early stage
- radiation therapy
- radiation induced
- machine learning
- circulating tumor cells
- risk assessment
- deep learning
- molecularly imprinted
- human health
- combination therapy
- case control
- walled carbon nanotubes