Opioid consumption and non-opioid multimodal analgesic treatment in pain management trials after hip and knee arthroplasties: A meta-epidemiological study.
Casper PedersenFrej Juul VilhelmsenJens LaigaardOle MathiesenAnders Peder Højer KarlsenPublished in: Acta anaesthesiologica Scandinavica (2023)
Post-operative 0-24 h morphine consumption was median 21-22 mg. The demonstrated differences in non-opioid multimodal analgesic regimens between research and clinical settings, can potentially diminish the demonstrated opioid-sparing effects of trial interventions when such are implemented in a clinical context.