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Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure.

Vandana MallaredyRajika RoyZhongjian ChengCharan ThejCindy BenedictMay TruongcaoDarukeshwara JoladarashiAjit MagadumJessica IbettiMaria CiminiCarolina GonzalezVenkata Naga Srikanth GarikipatiWalter J KochZhongjian Cheng
Published in: Circulation research (2024)
Our study underscores the pathological role of exosomes in HF and fibrosis in response to pressure overload. Tipifarnib-mediated inhibition of exosome biogenesis and cargo sorting may serve as a viable strategy to prevent progressive cardiac remodeling in HF.
Keyphrases
  • heart failure
  • acute heart failure
  • left ventricular
  • multiple sclerosis
  • stem cells
  • mesenchymal stem cells
  • liver fibrosis