Phellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma.

Yanpo SiChengcheng HuiTao GuoMengqi LiuXiaohui ChenChunhong DongShuying Feng

Published in: Journal of hepatocellular carcinoma (2023)

PDA exhibited the proliferation inhibition of SMMC-7721 cells by inhibiting ROS/Nrf2/Notch signaling pathway and significantly affected the metabolic profile, suggesting PDA could be a potential therapeutic agent for patients with hepatocellular carcinoma.

Keyphrases

signaling pathway
cell cycle arrest
induced apoptosis
pi k akt
cell death
oxidative stress
dna damage
cell proliferation
epithelial mesenchymal transition
reactive oxygen species
endoplasmic reticulum stress