Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury.
Chaoyan HanXin ZhaoXiao-Kui HuoZhenlong YuChao WangLei FengJing-Nan CuiXiang-Ge TianXiao-Chi MaPublished in: Chemical communications (Cambridge, England) (2023)
An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging. In addition, ERBM was applied to illustrate the regulation characteristics of CES1 under ER stress and acute liver injury models at the cell and animal level.
Keyphrases
- fluorescent probe
- liver injury
- drug induced
- living cells
- endoplasmic reticulum stress
- endoplasmic reticulum
- single cell
- induced apoptosis
- cell therapy
- adverse drug
- high resolution
- stem cells
- photodynamic therapy
- liver failure
- bone marrow
- cancer therapy
- mesenchymal stem cells
- fluorescence imaging
- estrogen receptor
- mass spectrometry
- real time pcr
- drug delivery
- drug release